The Cathedral of Termini Imerese was built during the fifteenth century, but significantly renovated during the Baroque period. Dedicated to St. Nicholas of Bari, it showcases a facade of recent construction (XX century) where there are sixteenth-century statues in the niches of the facade. Inside the Latin cross design, valuable statues are preserved, such as the Madonna of Mazza, made at the end of the fifteenth century and a beautiful wooden crucifix dating from the beginning of the last century.

The Civic Museum of Termini Imerese is constructed on the premises of the former fourteenth century hospital, where many interesting archaeological finds that trace the history of the city since prehistoric times are on display. Established in the nineteenth century, it holds over two floors of findings from Himera, such as lion heads, a copious epigraphic collection, beautiful marble sculptures and examples of paintings made ​​from the twelfth to the seventeenth century, most notably the Annunciation in Flemish style.